When you are devising your research question you may find it useful to do the following:
The key to your search strategy is to combine terms:
Use OR to check alternative terms for the key concepts eg
adolescen* OR "young people" OR teen* OR "young adult*" OR student or "young person*"
"mental health" OR wellbeing OR well-being OR depression OR anxiety
Combine the two concepts with AND to narrow down results that ONLY have a word from both lists.
"Or is More!"
If you are searching for studies of a particular design, there are a number of filters available that have been produced to simplify the task.
King's College London has a useful guide on this, see below:
Extract from Demystifying the Search Button - McKeever - 2015 - Journal of Parenteral and Enteral Nutrition - Wiley Online Library
The distinctive feature of a MEDLINE-indexed citation is the manual rigor under which it is cataloged and categorized. Highly skilled information technicians read each article to determine the key points as well as its smaller discussion points. These points are then manually catalogued under a series of searchable Medical Subject Headings (MeSH terms) and subheadings.5
The current staff that manages citations and MeSH terms at the NLM generally have a master's degree or higher in some form of biomedical field.6 Their collective expertise embraces a diverse range of biomedical topics. Each attends rigorous training in document analysis and cataloguing for MeSH (visible on the NLM website).7 They then complete an internship/apprenticeship with an indexing mentor who checks every indexed article for quality and consistency with MEDLINE cataloguing methodology.
The MeSH system is essentially a digital filing cabinet with 16 biomedical topic drawers that match to the broadest MeSH terms. These drawers are filled with a 12-tier hierarchy of folders within folders, which systematically narrow into increasingly refined topic areas; each topic area is accessible through its MeSH term. Each MeSH term comes with a selection of up to 83 possible subheadings to further refine the topic area to a specific focus of interest, such as the “adverse effects,” “economics,” “ethics,” or “methods,” associated with a specific term.7 This system is intricate, but all the tools necessary to simplify its navigation are available for use through PubMed.